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THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels - 60 Capsules - 5-MTHF 5mg

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4.7 922 ratings

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Amazon's Choice in Vitamin B9 (Folic Acid) Supplements by THORNE

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$60.00 $1.00 per Count

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Brand	THORNE
Item Form	Capsule
Primary Supplement Type	Vitamin-b
Diet Type	Gluten Free
Flavor	Unflavored

About this item

Healthy Methylation: A breakthrough in active folate supplementation for healthy methylation*
Positivity: Supports a healthy outlook*
Nerves & Circulation: Supports healthy blood vessel and nerve function*
Cardiovascular Support: Providing the nutritional cofactors for optimal homocysteine metabolism supports cardiovascular health*
Trusted: Thorne is chosen by champions and trusted by 100+ pro teams. Thorne is the only supplement manufacturer to collaborate with Mayo Clinic on wellness research and content. Thorne is also a proud partner of 11 U.S. Olympic Teams

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Foundational Wellness

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Reduced air and/or water in the product or packaging for more efficient transportation.

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Product Description

5-MTHF is an active, tissue-ready form of folate. It’s an essential B vitamin that supports healthy methylation, fetal development, positivity, and cardiovascular and nerve function.*


Greater Absorption Thorne's 5-MTHF includes an active ingredient that is tissue-ready and in its most bioavailable form for better use by the body.*	Clinically Studied One study found a 600-percent greater blood level of 5-MTHF after supplementation with 5-MTHF compared to folic acid supplementation.* (Source: Willems F, Boers G, Blom H, et al. Pharmacokinetic study on the utilization of 5-methyltetrahydrofolate and folic acid. . . . Br J Pharmacol 2004;141:825-830.)	Well-Researched Benefits In conjunction with vitamin B12, 5-MTHF functions as a methyl-group donor, which facilitates the conversion of the undersirable amino acid homocysteine to the more desirable methionine.* Methyl-group donation is vital to many necessary biochemical conversion processes, including the synthesis of serotonin, melatonin, and DNA.*	Trusted Manufacturer For more than 30 years, Thorne has been trusted by health-care practitioners who prescribe our products to their patients. In addition, our products are now recommended by U.S. National Teams and multiple professional sports teams for their elite athletes. Thorne products are a testament to Thorne's mission to provide high-quality supplements that are tested for quality, safety, and efficacy.

If supporting your heart and cardiovascular system is your objective, then diet will always play a big role. However, nutritional supplementation can partner with a healthy diet and exercise to provide additional support for blood vessel health, heart muscle function, maintenance of normal cholesterol, support for healthy blood pressure, and balanced methylation.* *FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease

When the highest standards have been met, Thorne creates higher ones.


Sourcing Exceptional Ingredients We develop better standards for higher quality ingredients. Thorne cares deeply about where our ingredients come from. We partner only with suppliers whose practices emphasize quality, science, and responsibility. Better ingredients means better potency, absorption, and digestibility - and ultimately better health.	Manufacturing the Right Way We manufacture our own products to ensure full supply chain transparency. For more than 30 years, we have invested in clean manufacturing practices. We refuse to use ingredients that can inhibit absorption. We perform our final production in the United States.	Four Rounds of Testing We perform four rounds of testing for each product we manufacture – far above the industry standard. Thorne has invested in two state-of-the-art in-house laboratories that enable us to conduct four rounds of testing, including raw material testing, in-process batch testing, finished product testing, and expiration date stability testing for each lot of product that we manufacture.	Our Impact We're thinking sustainably to protect our environment. We believe the environment should never be compromised for the sake of business gain. At Thorne, we believe that doing our part to protect the environment and its most valuable resources goes hand in hand with our product quality standards.

Focus on sustainability

Compact by design from Climate pledge friendly. Certified by Amazon.

Small changes in product size & weight lead to lower carbon emissions.

We created Compact by Design to identify products that, while they may not always look very different, have a more efficient design. With the removal of excess air and water, products require less packaging and become more efficient to ship. At scale, these small differences in product size and weight lead to significant carbon emission reductions.

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WARNING: California’s Proposition 65

Product details

Is Discontinued By Manufacturer ‏ : ‎ No
Item model number ‏ : ‎ B132
Date First Available ‏ : ‎ July 8, 2011
Manufacturer ‏ : ‎ Thorne Research
ASIN ‏ : ‎ B005BSMVFS
Country of Origin ‏ : ‎ USA

Best Sellers Rank: #15,202 in Health & Household (See Top 100 in Health & Household)
- #22 in Vitamin B9 (Folic Acid) Supplements
- #1,413 in Climate Pledge Friendly: Health and Household

Customer Reviews:
4.7 922 ratings

Compare with similar items

	This Item THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels - 60 Capsules - 5-MTHF 5mg	Recommendations L Methyl Folate 15mg plus Methyl B12 Cofactor - Professional Strength, Active 5-MTHF Form - Supports Mood, Methylation, Cognition – Bioactive forms of Vitamin B9 & B12 (60 Capsules)	dummy Nutri 5-MTHF L Methylfolate 15MG - 4 Month Supply, 120 Vegan Tablets - Methylated Folate Supplement - Cognitive Function, Heart Health, Prenatal Support - Methylated Folic Acid, MTHFR Supplement…	dummy Vimergy 5-MTHF, 60 Servings – Highly Absorbable Capsules – Supports Brain Health & Cognitive Function – Healthy Mood Support Supplement* - Non-GMO, Gluten-Free, Vegan & Paleo Friendly (60 Count)	dummy THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels - 60 Capsules - 5-MTHF 1mg	dummy THORNE Vitamin D + K2 Liquid with a metered Dispenser - Vitamins D3 and K2 to Support Healthy Bones and Muscles* - 1 Fl Oz (30 ml) - 600 Servings
	Try again! Details Added to Cart	Try again! Details Added to Cart	Try again! Details Added to Cart	Try again! Details Added to Cart	Try again! Details Added to Cart	Try again! Details Added to Cart
Price	$60.00	$21.99	$26.99	$44.00	$23.00	$29.00
Price Per Unit	$1.00 / Count	$0.37 / Count	$0.22 / Count	$0.73 / Count	$0.38 / Count	$29.00 / Fl Oz
Delivery	Get it as soon as Monday, May 13	Get it as soon as Monday, May 13	Get it as soon as Monday, May 13	Get it as soon as Monday, May 13	Get it as soon as Monday, May 13	Get it as soon as Monday, May 13
Customer Ratings	4.7922	4.54,121	4.6137	4.7285	4.72,806	4.55,063
Easy to swallow	4.8	4.6	5.0	4.5	4.8	4.3
Flavor	4.3	4.3	5.0	4.2	4.3	4.4
Absorbency	4.8	4.5	—	4.5	4.4	4.3
Value for money	4.2	4.6	5.0	—	4.3	4.6
Sold By	Pattern.	Triquetra Health	Nature's Fusions Nutri	Vimergy	Pattern.	Pattern.
primary supplement	Vitamin-b	Vitamin B12	Tablet	Vitamin B12, Vitamin B9	Vitamin-b	Vitamin D+K2
form	Capsule	Capsule	Tablet	Capsule	Capsule	Liquid
unit count	60	60	120	60	60	1
flavor	Unflavored	Unflavored	Unflavored	Unflavored	Unflavored	Unflavored
target gender	unisex	unisex	unisex	female	unisex	unisex
weight	5 milligrams	0 pounds	—	0.03 kilograms	1 milligrams	0.17 pounds
specific uses	Nerve	Brain	Methylfolate	—	Nerve	Bone

Important information

Safety Information

If pregnant, consult your healthcare practitioner before using this product. Interactions: 5-methyl-tetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate.

Indications

Nerve Support

Ingredients

One Capsule Contains: Folate (5 mg as L-5-Methyltetrahydrofolate) 8.3 mg DFE, Other Ingredients: Microcrystalline Cellulose, Hypromellose (derived from cellulose) capsule, Leucine, Silicon Dioxide.

Directions

Take 1 capsule one to two times daily or as recommended by your healthcare practitioner.

Legal Disclaimer

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Please contact your healthcare professional immediately if you experience any unwanted side effects. The information contained herein is for informational purposes only and does not establish a doctor-patient relationship. Please be sure to consult your physician before taking this or any other product.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

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Customer reviews

4.7 out of 5

922 global ratings

How customer reviews and ratings work

Customers say

Customers like the quality, performance, and energy of the vitamin. They mention that it's an excellent product, it helps with post partum depression, anxiety, neuropathy, and cognition and focus. They also say it helps restore their energy levels. Opinions are mixed on value and sleep.

AI-generated from the text of customer reviews

43 customers mention43 positive0 negative

Customers are satisfied with the quality of the 5-MTHF from Thorne. They mention it's an excellent product, a very good brand, and effective. Some say it'll hold up ok and is the best folate product.

"...Overall, a great formulation, subjectively I feel, undiluted. I plan to stick with this one as it works best out of 4 different brands I tried." Read more

"Product fine, slow to actually ship it out." Read more

"...Thorne is a very high quality company." Read more

"...Now it's way longer and holding up ok. I love that! Price is high though, no doubt." Read more

42 customers mention42 positive0 negative

Customers are satisfied with the performance of the vitamin. They mention that it helps tremendously with postpartum depression, anxiety, neuropathy, cognition, and focus. They also say that it's a helpful tool in the health of their child and improves symptoms. Customers also say the supplement gives a sense of well-being, wakefulness, and ease. They say that the 5 milligram capsules are essentially.

"...Rest is more restorative, detox systems work way better. Mood is not hampered by grogginess, and I can enjoy/handle more caffeine than before...." Read more

"...This is a great supplement to my nutrient-rich diet and I am confident that when it is time to begin child bearing, I will be even more thankful..." Read more

"I have autism/ADHD. This supplement has improved my symptoms. I felt disconnected from my body...." Read more

"...I'm taking this, my stiffness and joint pain decreases, and my anxiety decreases...." Read more

14 customers mention14 positive0 negative

Customers find the energy level of the vitamin to be better. They say it helps to restore their energy levels and control anxiety. They also say it keeps their metabolism functioning and helps with mood, depression, and chronic fatigue.

"...My energy level and focus improves when I'm taking this, my stiffness and joint pain decreases, and my anxiety decreases...." Read more

"...I have noticed an improvement in my migraines as they are happening less frequently. I am very happy with this product." Read more

"...I've noticed an increase in energy, not huge but enough to be encouraging as well as some mental clarity .... I quit taking anything that's..." Read more

"AMAZING SUPPLEMENT! I noticed my energy improve tremendously after taking. My thinking is clear and it simultaneously seems to calm my nerves...." Read more

21 customers mention10 positive11 negative

Customers are mixed about the value of the vitamin. Some mention it's worth the price, works better than less expensive brands, and is a perfect purchase. However, others say that it'd be better off with a less expensive brand.

"it is very expensive and i cannot tell if it is helping my situation." Read more

"...I’m Happy with my purchase, it is worth the cost!" Read more

"...Now it's way longer and holding up ok. I love that! Price is high though, no doubt." Read more

"...I'm thrilled Thorne released a 15mg capsule. so much more cost effective than taking three 5mg capsules a day...." Read more

8 customers mention5 positive3 negative

Customers are mixed about the sleep with some saying they feel tired and groggy, while others say they feel awake and eased. Some customers say the overall anxiety is down and they are less cranky. However, others have reported an anxiety attack and mood swings.

"...Rest is more restorative, detox systems work way better. Mood is not hampered by grogginess, and I can enjoy/handle more caffeine than before...." Read more

"...old son, after taking the 5 mg for about 4 days, had an anxiety attack with a racing heart and said he thought he was going to die...." Read more

"...promotion, and while taking the 10mg, one day I realized I felt pretty tired, unmotivated, and groggy...." Read more

"...Folate (Metafolin version) give a sense of well-being, wakefulness and ease...." Read more

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EugeneGTI

Worth the price

Reviewed in the United States on June 22, 2021

Verified Purchase

I found out about my hardcore MTHFR mutations about 6 years ago. At first I was taking lesser brand's formulation (also 15mg) which worked for a while, but then stopped (dissolvable lozenges). I stopped taking this about 18 months ago, because I felt no different with it or not. About a month ago I bought this one and the difference is very noticeable. Rest is more restorative, detox systems work way better. Mood is not hampered by grogginess, and I can enjoy/handle more caffeine than before. Overall, a great formulation, subjectively I feel, undiluted. I plan to stick with this one as it works best out of 4 different brands I tried.

18 people found this helpful

Helpful

Maitri Patel

Very nice.

Reviewed in the United States on September 30, 2023

Verified Purchase

Good medicine 💊. I recommend who planing to become pregnant 🤰.

Helpful

Rebecca

Worth a try if you have the gene mutation. For me, it's worth every penny

Reviewed in the United States on September 20, 2014

Verified Purchase

Both me and my husband have the gene mutation relating to methylfolate, I have the lesser of the two and my husband has the more aggressive gene. I'm just going to give my own experience, but I can tell you in brief that this has helped my husband as well.

(I started off with 1mg from the same brand, went all the way to 10mg (different brand), and am now settled at 5mg because it works just as well for me as the 10mg.)

This product has helped me so much. I was already in a pretty good part of my life when taking this, but part of me wishes that maybe my life would had been different if I had this during my highschool years when I was going through depression and other mental issues (especially memory related). I've since recovered from so much through changing my diet and lifestyle alone, but now that I'm at a great place in my life this supplement actually takes it to the next level. I initially began taking these as a precaution and for general health promotion, and while taking the 10mg, one day I realized I felt pretty tired, unmotivated, and groggy. I realized that I hadn't taken my 5-MTHF that day, and have had the same experience repeated if I forget to take the 5mg dose as well. It's pretty incredible, and very noticeable when you are very busy and depend on a varied, high quality source of nutrients every day to keep you going. This is a great supplement to my nutrient-rich diet and I am confident that when it is time to begin child bearing, I will be even more thankful that this product exists.

50 people found this helpful

Helpful

Shawn

the suppliment works well

Reviewed in the United States on March 25, 2024

Size: 60 Count (Pack of 1)Verified Purchase

the suppliment works if taken regularly, without fail.

Helpful

Brandon

Life changing

Reviewed in the United States on June 6, 2023

Size: 60 Count (Pack of 1)Verified Purchase

I have autism/ADHD. This supplement has improved my symptoms. I felt disconnected from my body. Like I was living in a video game watching my character. After a few days of this, I felt like I was back inside my body. I can’t even begin to describe all the things that have improved.

33 people found this helpful

Helpful

Amazon Customer

Waiting...waiting...

Reviewed in the United States on August 3, 2023

Size: 60 Count (Pack of 1)Verified Purchase

Product fine, slow to actually ship it out.

Helpful

badanimal

Thorne is a great company. It's pricey but cheaper than "Deplin" AND cleaner.

Reviewed in the United States on December 5, 2013

Size: 60 Count (Pack of 1)Verified Purchase

I don't think it's a 5 star for me...but when rating it..one star means "I hate it", 2 I like it, 3 it's ok, you catch my drift...:)

I know what I have read anyhow about MTHFR gene and that my good ol' lab states I'm one of the fortunate ones with this "Mutant" gene"..lovely word "Mutant." So, I am taking it because of the MTHFR gene issue...hoping like heck it would help with depression.

However I have been on..SSRI's, SNRI's, MAOI'S anti psycotics, name the drug for depression, or augmenting with another, I've been on it. I received samples of "Deplin" which many of you already know about "Deplin but at least with my samples that I was given it was 15 mg L-methlfolate.

When samples ran out..I ordered "Thorne" because (and another reason I refused to rate it low) it has historically been a very great company in my opinion. It could be me, it could be the fact I'm on so much other stuff that it's not doing what I'd love to experience like many that have said about it and/or deplin that it "helped significantly with depression"..and a biggie I hoped for I heard it helped with "motivation and energy" not I.

I'm not giving up on it, not yet anyway. and I hope to submit a less pessimistic post soon. Though I've given it over three months...and to reiterate, I'm on so much stuff, that the "stuff" may be keeping 5 MTHF (3 per day) from doing the miraculous, as it has for others...I'm very happy for the "others" just on a huge "pity party" for me..because again, again and again...I hope.."this may be the one that helps me get ANYTHING accomplished.." be it crappy things or things I WANT, NEED to do...ANYTHING!

So, I attempted a post in that, perhaps I can honestly say (though I have been most lengthy about it) I am not experiencing awesomeness, but perhaps a future post will say "hey, it's wonderful, hang in there any and everybody!" I hope so!

22 people found this helpful

Helpful

JJrocka

THE ABSOLUTE BEST!

Reviewed in the United States on January 5, 2016

Size: 60 Count (Pack of 1)Verified Purchase

I have severe chronic fatigue and Lyme Disease, I also have the MTHFR mutation, since the genetic defect was diagnosed about 2 years ago I have tried pretty much every methyl folate product out there, my conclusion is that although expensive Thorne 5- mthf is absolutely the best supplement available to treat us mutants.
My energy level and focus improves when I'm taking this, my stiffness and joint pain decreases, and my anxiety decreases.
If you choose to supplement with this product it's important to start at a low dose, I would recommend starting with the 1 mg dose and gradually working your way up to the 5, you could make yourself sick otherwise as your body may not be able to handle such a big increase in folate all at once.
It is also important to take a high quality B- complex supplement like Integrative Therapeutics multi B along with this as your body will need all of the other forms of vitamin B in order to properly absorb and burn methyl folate.
Good Luck

178 people found this helpful

Helpful

Disclaimer: While we work to ensure that product information is correct, on occasion manufacturers may alter their ingredient lists. Actual product packaging and materials may contain more and/or different information than that shown on our Web site. We recommend that you do not solely rely on the information presented and that you always read labels, warnings, and directions before using or consuming a product. For additional information about a product, please contact the manufacturer. Content on this site is for reference purposes and is not intended to substitute for advice given by a physician, pharmacist, or other licensed health-care professional. You should not use this information as self-diagnosis or for treating a health problem or disease. Contact your health-care provider immediately if you suspect that you have a medical problem. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease or health condition. Amazon.com assumes no liability for inaccuracies or misstatements about products.

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THORNE 5-MTHF - Methylfolate (Active B9 Folate) Supplement - Supports Cardiovascular Health, Fetal Development, Nerve Health, Methylation, and Homocysteine Levels - 60 Capsules - 5-MTHF 5mg

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PRODUCT CERTIFICATION (1)

From the brand

Foundational Wellness

Sports Nutrition

Sustainability features

Product Description

Greater Absorption

Clinically Studied

Well-Researched Benefits

Trusted Manufacturer

When the highest standards have been met, Thorne creates higher ones.

Sourcing Exceptional Ingredients

Manufacturing the Right Way

Four Rounds of Testing

Our Impact

Focus on sustainability

Small changes in product size & weight lead to lower carbon emissions.

Here are a few of the many ways products can qualify:

Product details

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